http://antihypertensives.info/hypertension/how-does-angiotensin-converting-enzyme-ace-know-to-interact-with-angiotensin-i-instead-of-angiotensinogen/ Hypertension Medication Tue, 08 Jun 2010 11:09:31 -0500 http://wordpress.org/?v=2.8 hourly 1 http://antihypertensives.info/hypertension/how-does-angiotensin-converting-enzyme-ace-know-to-interact-with-angiotensin-i-instead-of-angiotensinogen/comment-page-1/#comment-57 Carlos Thu, 11 Mar 2010 03:34:26 +0000 http://antihypertensives.info/hypertension/how-does-angiotensin-converting-enzyme-ace-know-to-interact-with-angiotensin-i-instead-of-angiotensinogen/#comment-57 angiotensinogen is 452 amino acids long. after renin is activated it cleaves the Luecine and Valine bond in the first 12 amino acids. this leaves you with a 10 amino acid peptide. which then ACE interacts with angiotensin 1 one by removing the HIS and Leu amino acids at the end of the ten-amino acid peptide. It cannot interact with angiotensinogen because i'm guessing its too big. angiotensinogen is 452 amino acids long. after renin is activated it cleaves the Luecine and Valine bond in the first 12 amino acids. this leaves you with a 10 amino acid peptide. which then ACE interacts with angiotensin 1 one by removing the HIS and Leu amino acids at the end of the ten-amino acid peptide. It cannot interact with angiotensinogen because i’m guessing its too big.

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