Angiotensin Receptor Blockers as a choise in hypertension treatment
Angiotensin II receptor blockers are chemical substances commonly used worldwide in treatment of high blood pressure. According to their name Angiotensin receptor blockers they have a blocking action on Angiotensin II receptors. This leads to remarkable decrease in blood pressure. To get the idea about how these type of drugs work you need to know first about what is called Angiotensin.
Angiotensin is a potent vasoconstrictor substance that is secreted inside the body to act on blood vessels walls to decrease blood vessels diameter hense increase the blood pressure. It’s secreted in an idle form that is called Angiotensinogen then with the help of Angiotensin converting enzymes is converted to the working form of Angiotensin.
Angiotensin receptor antagonists that have acronyam ARBs (Angiotensin Receptor Blockers) has been formulated with many pharmaceutical companies like Astra Zenica, Nouvartis, Merk Sharp and Dhome and many more to marketed products like ATACAND, DIOVAN, COZAAR, MICARDIS, APROVEL and many more.
ARBs are all ends up with sartan like Losartan in COZAAR, Valsartan in DIOVAN, Candesartan in ATACAND, Telmisartan in MICARDIS.
Angitensin receptor blockers have been used in treatment of hypertension beside heart problems like CHF (congestive heart failure) and kindney disfunction.
ARBs action can be boosted by accompanying with Diuretics like Hydrochlorothiazides or loop diuretics . Diuretics increase potency of Angiotensin Receptor blockers but potassium level should be monitored as this combination deplete potassium.
Angiotensin receptors antagonists are avoided completly during pregnancy specially the first trimesters as they were indicated to increase possibilty of featus malformation
