Antihypertensive Drugs

[caption id="attachment_70" align="alignright" width="343" caption="TARKA® (trandolapril/verapamil hydrochloride ER)"][/caption]

Chemical composition:

TARKA® consists of a combination of slow release formula of Verapamil (Calcium channel blocker) and immidiate release formula of Trandolapril (ACE inhibitor)

Verapamil formulated as verapamil hydrochloride which is white crystalline powder soluble in water and alcohol, odourless and has bitter taste. Trandolapril is the ethyl ester of the active forumla tradolaprilate. Trandolapril is colourless crystalline powder soluble in methanol and chloroform

TARKA also contains the following ingredients: lactose, microcrystalline cellulose, ethanol, corn starch, dioctyl sodium sulfosuccinate,  hydroxypropyl cellulose, hypromellose, , magnesium stearate,  polyethylene glycol, silicon dioxide, povidone, purified water ,sodium stearyl fumarate,  sodium alginate,  talc, synthetic iron oxides,  and titanium dioxide.

TARKA® has 4 strengthes 2/180mg, 1/240mg, 2/240mg, 4/240mg as trandolapril/verapamil.

[caption id="attachment_51" align="alignright" width="255" caption="Azor"][/caption]

The United States food and drug adminstration (FDA) approved Azor as first line treatment for high sever blood pressure. AZOR is formulated by Daiichi Sankyo, Inc. It’s a combination of Amlodipine as Amlodipine besylate and Olmesartan medoxomil. It’s prescribed for patients suffering from high blood pressure that can’t be controlled by the normal single antihypertensive theraby.

Exforge is a new antihypertensive medication produced by Novartis pharma. It combines between two main antihypertensive classes (Angiotensin Receptor Blockers as Valsartan and Calcium channel Blockers as Amlodipine). It’s been prescribed by doctors in case of chronic high blood pressure when one drug is not enough.