Indapamide is the first choice for hypertension
Indapamide (marketed by Servier as Natrilix SR) is a thiazide-like diuretic. It inhibits Na/Cl reabsorption from the distal convulated tubules in the kidneys. It lower the blood pressure by inducing diuresis which means a fall in blood volume and decreasing on cardiac output. When taking for prolonged it causes lowering in peripheral resistance.
Indapamide may induces some side effects like fatigue, allergy, rarely skin rash, vertigo and hypokalemia (decreasing potassium level in serum).
Daily dosage is to be one tablet daily in early morning.
Indapamide is contra-indicated in patients having renal impairment, liver failure or hypokalemia.
Interaction activity shown with Lithium so it should be avoided to be taken with any Lithium therapy and nonantiarrhythmic drugs like bepridil, terfenadine, sultopride and vincamine.